METHADONE GUIDELINE FOR DUMMIES

[sixty one] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that's fewer strong being an opioid, is a lot more powerful at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone provides a lower affinity, with an IC5